Homochiral Metal–Organic Framework [Co(L)(bpe)2(H2O)2]·H2O Used for Separation of Racemates in High-Performance Liquid Chromatography

Abstract A homochiral metal–organic framework (MOF) comprising [Co(L)(bpe)2(H2O)2]·H2O was prepared using (1R,2R)-(−)-1,2-cyclohexanedicarboxylic acid (H2L) and 1,2-bis(4-pyridyl)-ethylene as organic ligands. The MOF explored chiral stationary phase (CSP) for high-performance liquid chromatography (HPLC) separation of racemates. Nine racemates including naphthol, alcohol, diol, amine, ketone, ether were well separated on the column (250 mm long × 4.6 i.d.). relative standard deviation five replicate separations 1,1′-bi-2-naphthol is 0.69% retention time, indicating that good reproducibility stability HPLC enantioseparation. results indicated CSP practical, which promotes application MOFs in HPLC.